ABSTRACT
Purpose: To evaluate the anti-SARS CoV-2 effect of Coenzyme Q 10, Ubiquinol-10, and idebenone, which have beneficial therapeutic applications against diverse virus types, using molecular docking approach. Methods: The potential activity of Coenzyme Q10, Ubiquinol-10, and Idebenone against viral infections was explored through the collection of data from relevant literature, and by modelling these compounds virtually, using in silico investigation methods. Results: Coenzyme Q10 and ubiquinol-10 showed significant docking performance. They interacted with numerous amino acid residues of the main protease of SARS-CoV-2 ACE2 (7C8J), Alpha thrombin (1AE8), TYRO (4TS1) protein targets sides, SARS-coronavirus Orf7a accessory protein (1XAK), TNF (1RJ8), and Cytokine/receptor (1I1R). Conclusion: The findings of our study showed promising inhibitory activities of the selected compounds against the main proteases of SARS-CoV-2. Consequently, these compounds have theoretical effects on inhibiting the viral entry, reproduction, and ultimately the prevention and/or treatment of the SARSCoV2 infection.
ABSTRACT
The coronavirus disease 2019 (COVID-19) pandemic, the most important public health problem in 2020, poses severe health and socioeconomic impact. Many people turn to herbal therapy to prevent infection with the virus or alleviate the symptoms caused by it. This study evaluates the patterns of phytotherapy-based product utilization in the prevention against SARS-COV-2 and their reported effectiveness. This cross-sectional survey used a convenience sample of 287 adults who had used any form of phytotherapeutics to help fight and/or treat COVID-19 infection. The majority (n = 194, 67.6%) of participants had used plants from the Rutaceae family (like lemon and oranges), followed by those of Amaryllidaceous (namely, Garlic and Onion). Participants said that physicians and pharmacists were the primary sources of information about phytotherapy (n=107, 37.3%), and their decision was driven by their positive attitude towards herbal medicine or plant-based products (n=133, 46.3%). Many participants did not notice any side effects of these remedies (n=270, 94%) and believed they were effective (n = 184, 64%). This study provides an overview of the many phytotherapeutic remedies used in the era of COVID-19 by Jordanian society, which could prompt the conduction of interventional trials to assess the effectiveness and safety of this modality of therapy, either as a stand-alone or adjuvant treatment. © 2021 the authors.
ABSTRACT
COVID-19 pandemic has spread across the world, which considered a relative of the severe acute respiratory syndrome (SARS), with possibility of transmission from animals to human and effect each of health and economic. Several preventative strategies and non-pharmaceutical interventions have been used to slow down the spread of COVID-19. The questionnaire contained 36 questions regarding the impact of COVID-19 quarantine on children‘s behaviors and language have been distributed online (Google form). Data collected after asking parents about their children behavior during quarantine, among the survey completers (n=469), 42.3% were female children, and 57.7 were male children. Results showed that quarantine has an impact on children‘s behav-iors and language, where stress and isolationism has a higher effect, while social relations had no impact. The majority of the respondents (75.0%) had confidence that community pharmacies can play an important role in helping families in protection their children‘s behaviors and language as they made the highest contact with pharmacists during quarantine. One of the main recom-mendations that could be applied to help parents protection and improvement their children‘s behaviors and language in quarantine condition base on sim-ple random sample opinion is increasing the role of community pharmacies inpatient counseling and especially towards children after giving courses to pharmacists in child psychology and behavior. This could be helpful to family to protect their children, from any changing in them behaviors and language in such conditions in the future if the world reface such the same problem.